Topical Morphine in the Treatment of Painful Ulcers
نویسندگان
چکیده
منابع مشابه
Treatment of painful sickle cell leg ulcers with topical opioids.
Leg ulceration is a common and painful complication of sickle cell anemia (SS). Leg ulcers tend to be indolent and intractable and heal slowly over months or years. The pain of these ulcers may be severe, excruciating, penetrating, sharp, and stinging in nature. In most patients, oral or parenteral opioid analgesics may be needed to achieve some pain relief. We wish to report our experience wit...
متن کاملTreatment of painful skin ulcers with topical opioids.
Recent research suggests that opioid receptors on peripheral nerve terminals may play an important role in the modulation of pain. Clinical applications of this knowledge have been rather slow to evolve. We describe a consecutive series of nine patients with painful skin ulcers due to a variety of medical conditions. All patients were treated with a topical morphine-infused gel dressing. Seven ...
متن کاملTopical morphine gel in the treatment of painful leg ulcers, a double-blind, placebo-controlled clinical trial: a pilot study.
Chronic painful wounds, a major health problem, have a detrimental impact on the quality of life due to associated pain. Some clinical reports have suggested that local administration of morphine could be beneficial. The aim of this study was to evaluate the analgesic effect of topically applied morphine on chronic painful leg ulcers. Twenty-one patients were randomly assigned to receive either...
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In a single-blind, randomized trial, the efficacy of topical streptokinase-streptodornase (Varidase@) solution was compared with that of zinc oxide on necrotic pressure ulcers in 28 patients. The effectiveness was determined by measuring the necrosis removal within 8 weeks. This occurred in 6 patients (43%) treated with Varidase@ and in 7 (50%) treated with zinc oxide. The statistical tests app...
متن کاملManaging painful venous ulcers.
P atients with venous ulcers often report pain, which may be continuous or intermittent and often is associated with dressing changes. The pain may be perceived as generalized in the leg, focused in the ulcer or periwound, or both. Inflammation and edema resulting from the underlying venous disease are key factors in the patient’s pain. Appropriate wound care combined with continuous use of com...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 2005
ISSN: 0885-3924
DOI: 10.1016/j.jpainsymman.2005.08.011